Invited Faculty
  • Je-Hwang Ryu
    Chonnam Nat'l Univ.
    Korea
  • Dr. Ryu elucidated the diverse roles of hypoxia-inducible factor-2α in rheumatoid arthritis (RA) and osteoporosis, and demonstrated the role of LRP5 in osteoarthritis (OA). Dr. Ryu has been trying to resolve the link between hard-tissue disease and other metabolic disorders. As a result, he identified the correlation between RA and obesity-causing genes and also found genes that control the close correlation between RA and periodontitis. Recently, Dr. Ryu’s lab also experimentally demonstrated the direct correlation between cholesterol abnormalities and cartilage destruction for the first time. Dr. Ryu’s research indicate that OA is a disease associated with metabolic disorders and suggest that targeting the CH25H-CYP7B1-RORa axis of cholesterol metabolism may provide a therapeutic avenue for treating OA. This research paper has been highly recognized in the field and were published in Nature (2019), one of world’s top academic journals. Dr. Ryu serves as an academic board member of KSMCB (Korean society for molecular and cellular biology), KSBMR (Korean society for bone and mineral research) and KSCO (Korean society for cartilage and osteoarthritis).
    Research & Clinical Focus

    cartilage

    osteoarthritis

    bone

    osteoporosis

    periodontitis

    • Date Time Room Session Title Lecture Title
    May 19 14:00-14:30 Room B [Workshop] Basic Research Workshop for Rheumatologist: Animal Models of Key Arthropathies Animal models of osteoarthritis (OA)